Buonsenso&theKids

Buonsenso&theKids

Could Intravenous Immunoglobulin (IVIG) Help in Long Covid and ME/CFS?

A clinical overview for families and physicians — by Buonsenso and the Kids

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MD, PhD
Sep 07, 2025
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Intravenous immunoglobulin (IVIG) is not a new therapy — it’s been used for decades to treat autoimmune and inflammatory conditions, including neurological syndromes. But in recent years, its use is being explored in post-viral syndromes like Long Covid and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) — particularly when these conditions present in children and adolescents with signs of immune dysfunction.

In this post, we’ll explore:

  • Why IVIG might help

  • The current evidence

  • Pros and cons of treatment

  • Monitoring response and side effects

  • What a reasonable protocol might look like


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