Thank you so much for your persistent & excellent work! In my opinion, we will not find the single treatment. The problem is multi-causal and multi-systemic based on the individual history of the affected person. We have to think “holistic”.
I couldn't agree more. This disorder, preceded by one equally complex is a multifactorial, multi systemic disorder that needs a therapeutic that addresses many of them. I/we base our concepts for our successful compassionate-use repurposed drug on some basic science with pre-clinical experiments and 5+ years of clinical observation of patients. Many suffered with mild-moderate and advanced COVID-19 to the point of respirator support, swallowing dysfunctions, and immobility. Thus far, there have been no reports of long Covid, subsequent to our unique protocol utilized successfully with all variants to date. The focus for current treatments of acute and long Covid has been misguided or misdirected by the failure to simultaneously address the need to block the gateway at the ACE2-RBD S-protein site, disruption of viral replication, and target the immune dysfunction at the most critical a7nAChRs. Our focus from the outset of the pandemic in January-February 2020 has been the multiplicity of pharmacodynamic functions of a well studied and safe repurposed drug, hydroxyUREA. This drug has been a main stay for sickle cell disease for over four decades and has been studied and prescribed extensively throughout the world. Comparisons of the pathophysiology of these two diseases, COVID-19 and sickle cell disease, was a topic with references kindly published under one of Dr. Buonsenso's recent substacks to which the reader is referred.
Great to hear! I would love to learn more about your protocol! Is there a chance to connect? If you find the time and effort, please write me a mail: info@drmeddiegoschmidt.com 🙏🏻
Please don't give up. We need you to understand what's behind. We, the patients' caregivers, have witnessed the link between Covid infection and neuropsychiatic diseases; we're sure since the very beginning of this, however, we need to find a way to manage, reduce and prevent future impacts. The worst is fearing that not reverting some mechanism still active behind, we're not preventing future worsening of the symptoms or even worse, degenerating diseases. This is a nightmare in the nightmare. We' re willing to put our experience and to make our beloved case available for further analysis to find out any new path of action, for her benefit and for anyone else. We're convinced that if we revert, reduce or contain the physical mechanisms behind, we'll be able to restore equilibrium at a psychical level as well, hoping that the damage is not a permament one. We perfectly imagine how hard is to research and work alone, and how overwhelming it may have become, but please go on because a psychiatric disease has a tremendous impact on individuals' lives and their families, and we believe that the issue might be underestimated as many people and medicians have no awareness of the origin of their issues. There should be a wide screening in order to find out the common traits and abnormal parameters that are common to the majority of patients, and then a trial. This implies funding, joining knowledges and experiences, rising the public's awareness...
Please don't give up.
And we're willing to contribute at any possible level , with our case study and with pur experience.
Thank you so much for your persistent & excellent work! In my opinion, we will not find the single treatment. The problem is multi-causal and multi-systemic based on the individual history of the affected person. We have to think “holistic”.
I couldn't agree more. This disorder, preceded by one equally complex is a multifactorial, multi systemic disorder that needs a therapeutic that addresses many of them. I/we base our concepts for our successful compassionate-use repurposed drug on some basic science with pre-clinical experiments and 5+ years of clinical observation of patients. Many suffered with mild-moderate and advanced COVID-19 to the point of respirator support, swallowing dysfunctions, and immobility. Thus far, there have been no reports of long Covid, subsequent to our unique protocol utilized successfully with all variants to date. The focus for current treatments of acute and long Covid has been misguided or misdirected by the failure to simultaneously address the need to block the gateway at the ACE2-RBD S-protein site, disruption of viral replication, and target the immune dysfunction at the most critical a7nAChRs. Our focus from the outset of the pandemic in January-February 2020 has been the multiplicity of pharmacodynamic functions of a well studied and safe repurposed drug, hydroxyUREA. This drug has been a main stay for sickle cell disease for over four decades and has been studied and prescribed extensively throughout the world. Comparisons of the pathophysiology of these two diseases, COVID-19 and sickle cell disease, was a topic with references kindly published under one of Dr. Buonsenso's recent substacks to which the reader is referred.
Great to hear! I would love to learn more about your protocol! Is there a chance to connect? If you find the time and effort, please write me a mail: info@drmeddiegoschmidt.com 🙏🏻
do you think something similar applies to the cognitive impairment of ME/CFS patients.?
100% think so
Dott.Buonsenso lo ringrazio delle notizie che ci dà. Vorrei sapere ibam.della vostra associazione di ricerca ,grazie
non abbiamo ancora una associazione di ricerca dove raccogliamo separatamente fondi per questa patologia, grazie per il pensiero
which antivirals do you use?
Italiano
Please don't give up. We need you to understand what's behind. We, the patients' caregivers, have witnessed the link between Covid infection and neuropsychiatic diseases; we're sure since the very beginning of this, however, we need to find a way to manage, reduce and prevent future impacts. The worst is fearing that not reverting some mechanism still active behind, we're not preventing future worsening of the symptoms or even worse, degenerating diseases. This is a nightmare in the nightmare. We' re willing to put our experience and to make our beloved case available for further analysis to find out any new path of action, for her benefit and for anyone else. We're convinced that if we revert, reduce or contain the physical mechanisms behind, we'll be able to restore equilibrium at a psychical level as well, hoping that the damage is not a permament one. We perfectly imagine how hard is to research and work alone, and how overwhelming it may have become, but please go on because a psychiatric disease has a tremendous impact on individuals' lives and their families, and we believe that the issue might be underestimated as many people and medicians have no awareness of the origin of their issues. There should be a wide screening in order to find out the common traits and abnormal parameters that are common to the majority of patients, and then a trial. This implies funding, joining knowledges and experiences, rising the public's awareness...
Please don't give up.
And we're willing to contribute at any possible level , with our case study and with pur experience.
thanks a lot, your message contains a lot of important take home messages from several perspectives
YOU WILL! 💪🏻